synthesis and antibacterial activity of some heterocyclic chalcone analogues alone and in combination with antibiotics

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ID: 241301
2012
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Abstract
A series of simple heterocyclic chalcone analogues have been synthesized by Claisen Schmidt condensation reactions between substituted benzaldehydes and heteroaryl methyl ketones and evaluated for their antibacterial activity. The structures of the synthesized chalcones were established by IR and <sup>1</sup>H-NMR analysis. The biological data shows that compounds <strong>p<sub>5</sub></strong>, <strong>f<sub>6</sub></strong> and <strong>t<sub>5</sub></strong> had strong activities against both susceptible and resistant <em>Staphylococcus aureus </em>strains, but not activity against a vancomycin and methicillin resistant <em>Staphylococcus aureus</em> isolated from a human sample. The structure and activity relationships confirmed that compounds <strong>f<sub>5</sub></strong>, <strong>f<sub>6</sub></strong> and <strong>t<sub>5</sub></strong> are potential candidates for future drug discovery and development.
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do2012moleculessynthesis Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Tuong-Ha Do;Thi-Ngoc-Phuong Huynh;Khac-Minh Thai;Cat-Dong Tran;Thanh-Dao Tran;Thi-Thao-Nhu Nguyen
Journal Journal of ethnopharmacology
Year 2012
DOI
10.3390/molecules17066684
URL
http://www.mdpi.com/1420-3049/17/6/6684
Keywords
synthesis antibacterial chalcone

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