the relatioships among leptin, resistin, visfatin, transforming growth factor (tgf)-β level and the severity grade of osteoarthritis in osteoarthritis patients with obesity

Obesity is risk factor for osteoarthritis (OA), that increased production of adipokine from adipocyte, such as leptin, adiponectine, resistin and visfatin. Some studies showed there was a relationship between adipokine level in sinovial fluid and incidence of OA. To determine the relationships among leptin, resisitin, visfatin, TGF-β level and the severity grade of osteoarthritis in osteoarthritis patients with obesity. Observational case-series study. The ethical clearance of this study had been approved by bioethics and humaniora unit Faculty of Medicine Sriwijaya University, Indonesia. Osteoarthritis patients with obesity in Internal Medicine Outpatient Dr. Mohammad Hoesin General Hospital, Palembang, South Sumatera, Indonesia were selected as subjects in this study, from April 2013 – February 2014. Level of TGF-β, leptin, resistin and visfatin were assayed by ELISA. The relationships was analysis by correlation-spearman rho test, p<0,05. There was moderate correlation among leptin, resistin, TGF-β level and the severity grade of OA in male and female patients. It was strong correlation among leptin, resistin, TGF-β level in sinovial and the severity grade of OA Kellgren-Lawrence in female patients .There was relationships among leptin, resistin, TGF-β level and the severity grade of OA.