synthesis of two isomers of 3-amino-7α-12α-dihydroxy-5β-cholanic acid
Clicks: 206
ID: 240896
2015
Article Quality & Performance Metrics
Overall Quality
Not rated
Combines reader engagement with the AI quality analysis. This
article has not been analysed, so there is no overall score —
reader engagement is measured and shown alongside.
Reader Engagement
Steady Performance
30.0
/100
206 views
35 readers
AI Quality Assessment
Not analyzed
Readership in this journal
SteadyRanked #19 of 30 articles by views in current opinion in structural biology
Most read
Least read
Bar heights use a square-root scale.
Mint this article as an NFT
Not yet mintedCreate a permanent, verifiable on-chain record of this article on the Scimatic Network. The NFT is held in your Journament account, and you can withdraw it to your own wallet at any time.
5
SUSD
one-off · no wallet required
Abstract
Aim.With the aim of differences investigation in physical-chemical properties optimized synthesis of the two stereoisomers of 3-amino-7-12-dihydroxycholanic acid has been performed.
Methods and results.As the source compound natural cholic acid was used. 3α-amino-7α-12α-dihydroxy-5β-cholanic acid was obtained in high yield and low number of by-products. The yield of 3β-amino-7α-12α-dihydroxy-5β-cholanic acid was low because of steric interference and process needed additional treatment stages. Column chromatography was used for cleaning compounds. The structure was studied and confirmed by NMR method. Significant differences in signals of NMR spectra and physical-chemical properties 3β-amino-7α-12α-dihydroxy-5β-cholanic acid and 3α-amino-7α-12α-dihydroxy-5β-cholanic acid wasn’t found or observed.
| Reference Key |
2015aktualnsynthesis
Use this key to autocite in the manuscript while using
SciMatic Manuscript Manager or Thesis Manager
|
|---|---|
| Authors | ;D. O. Barsuk ;S. M. Kovalenko |
| Journal | current opinion in structural biology |
| Year | 2015 |
| DOI |
10.14739/2409-2932.2015.1.41342
|
| URL | |
| Keywords |
Citations
No citations found. To add a citation, contact the admin at info@scimatic.org
Comments
No comments yet. Be the first to comment on this article.