lesão renal aguda por glicerol: efeito antioxidante da vitis vinifera l acute kidney injury by glycerol: antioxidant effect of vitis vinifera l

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ID: 240801
2007
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Abstract
JUSTIFICATIVA E OBJETIVOS: A lesão renal aguda (LRA) é a complicação mais grave da rabdomiólise. Nessa síndrome, a liberação do pigmento heme desencadeia uma lesão que se caracteriza por vasoconstrição glomerular e toxicidade celular direta com provável componente oxidante. A renoproteção com antioxidantes tem demonstrado efeito satisfatório. As proantocianidinas são antioxidantes naturais encontradas no extrato da semente da uva. O objetivo deste estudo foi avaliar o efeito antioxidante da Vitis vinifera sobre a função renal de ratos submetidos à lesão induzida por rabdomiólise. MÉTODO: Foram utilizados ratos Wistar, machos e adultos pesando entre 250 e 300 g. A LRA foi induzida pela administração de glicerol 50% por via muscular. Os animais foram distribuídos em 4 grupos: grupo Salina (6 mL/kg de NaCl a 0,9%), por via intraperitoneal (dose única), Glicerol (6 mL/kg) por via muscular metade da dose em cada região femoral, em dose única, grupo Vitis vinifera (3 mg/kg/dia), por via oral durante cinco dias e grupo Glicerol + Vitis vinifera que recebeu Vitis vinifera por cinco dias antes do glicerol. RESULTADOS: Foram avaliados a função renal (FR) e o perfil oxidativo (peróxidos urinários FOX-2 e MDA-TBARS). O grupo glicerol de animais tratado com Vitis vinifera apresentou melhora da FR e redução dos níveis de peroxidação lipídica. CONCLUSÕES: Os resultados deste estudo confirmaram a ação antioxidante da Vitis vinifera na LRA induzida por glicerol.
BACKGROUND AND OBJECTIVES: The Acute Kidney Injury (AKI) is the most serious complication of rhabdomyolysis. In this syndrome, the delivery of heme pigment induces an injury that distinguishes itself by glomerular vasoconstriction and direct cellular toxicity with oxidative component. The renoprotection with antioxidants has demonstrated satisfactory effect. The proanthocyanidins are natural antioxidants found in the grape seed extract. The aim of this study was to evaluate the antioxidant effect of Vitis vinifera (grape seed extract) on the renal function of rats submitted to the injury by rhabdomyolysis. METHODS: Wistar rats, male, adults, weight ranging from 250-300g were used. The AKI was induced by intramuscular administration of glycerol 50%. The animals were distributed in 4 groups: Saline group (6 mL/kg of NaCl 0.9% intraperitoneal once a day), Glycerol group (6 mL/kg) of intramuscular glycerol each femoral region received 3 mL/kg of glycerol, once a day), Vitis vinifera group (3 mg/kg/day v.o by 5 days) and Glycerol + Vitis vinifera by 5 days before glycerol). RESULTS: Renal function (RF-creatinine clearance) and oxidative profile (urinary peroxides-FOX-2 and MDA-TBARS) were evaluted. The Glycerol group treated with Vitis vinifera has shown improvements in RF and reduction levels of lipid peroxidation. CONCLUSION: The results of this study have confirmed the antioxidant protection of Vitis vinifera in AKI induced by glycerol.
Reference Key
martim2007revistaleso Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Elisabete Cristina de Oliveira Martim;Carolina Ferreira Pinto;Mirian Watanabe;Maria de Fátima Fernandes Vattimo
Journal Database : the journal of biological databases and curation
Year 2007
DOI
10.1590/S0103-507X2007000300004
URL
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0103-507X2007000300004
Keywords
antioxidant flavonoids acute kidney injury proanthocyanidins critical care first aid intensive care

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