assessment of single cell rna-seq normalization methods
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ID: 240419
2017
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Abstract
We have assessed the performance of seven normalization methods for single cell RNA-seq using data generated from dilution of RNA samples. Our analyses showed that methods considering spike-in External RNA Control Consortium (ERCC) RNA molecules significantly outperformed those not considering ERCCs. This work provides a guidance of selecting normalization methods to remove technical noise in single cell RNA-seq data.
| Reference Key |
ding2017g3:assessment
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|---|---|
| Authors | ;Bo Ding;Lina Zheng;Wei Wang |
| Journal | separation and purification technology |
| Year | 2017 |
| DOI |
10.1534/g3.117.040683
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| URL | |
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