pathology of nonalcoholic fatty liver disease (nafld) associated with obesity: pathogenetic mechanisms

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ID: 239918
2011
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Ranked #26 of 54 articles by views in american journal of transplantation : official journal of the american society of transplantation and the american society of transplant surgeons

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Abstract
Non-alcoholic fatty liver disease (NAFLD) is the most important cause of chronic liver disease and is considered the hepatic manifestation of the metabolic syndrome associated with obesity and diabetes type 2. NAFLD refers to a wide spectrum of liver damage, including simple steatosis and inflammation, fibrosis, and cirrhosis (non-alcoholic steatohepatitis). The mechanisms involved in NAFLD are multifactorial, insulin resistance being a common factor in the retention of fatty acids and triacylglycerides within hepatocytes with mitochondrial production of free radicals, which trigger oxidative stress, cytokine production, and necrosis. Concomitantly, reduced availability of long chain n-3 polyunsaturated fatty acids is attained, a condition that alter the function of several transcription factors involved in lipolytic and lipogenic processes in the liver. A greater knowledge of the etiopathogenic mechanisms of NAFLD is crucial for the development of future effective therapeutic strategies.
Reference Key
videla2011medwavepathology Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Luis Alberto Videla;Ana María Obregón;Paulina Pettinelli
Journal american journal of transplantation : official journal of the american society of transplantation and the american society of transplant surgeons
Year 2011
DOI
DOI not found
URL
http://dx.doi.org/10.5867/medwave.2011.07.5068
Keywords
obesidad resistencia insulínica ácidos grasos poli-insaturados de cadena larga de la serie n-3medicinemedicine (general)

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