fatores associados à sobrevida em pacientes submetidos a transplante cardíaco utilizando microcardioplegia sanguínea retrógrada associated factors with survivals in patients undergoing orthotopic heart transplant using retrograde blood microcardioplegia
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2012
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Abstract
INTRODUÇÃO: Uma grande variedade de técnicas e soluções é utilizada na preservação do coração durante o transplante, o que demonstra a falta de método ideal na prática clínica. A administração da cardioplegia de forma retrógrada propicia perfusão contínua, o que pode conferir melhor recuperação inicial do coração transplantado. O objetivo deste trabalho é descrever a experiência de um único centro onde todos os pacientes receberam a mesma solução de conservação de órgão e foram submetidos a microcardioplegia sanguínea retrógrada contínua durante o implante do enxerto e avaliar fatores de mortalidade precoce e tardia com a utilização desta técnica. MÉTODOS: Este é um estudo retrospectivo, observacional e descritivo, realizado em um único centro. RESULTADOS: No período do estudo, foram realizados 35 transplantes cardíacos, sendo que 15 (42,9%) pacientes encontravam-se em choque cardiogênico. A probabilidade de sobrevida foi 74,8±7,8%, 60,4±11,3% e 15,1±13,4% ao final de 1 ano, 5 anos e 10 anos de seguimento, respectivamente. O tempo médio de sobrevida foi de 96,6 meses. CONCLUSÃO: A utilização da solução cardioplégica para proteção de órgãos e a estratégia de iniciar a perfusão com microcardioplegia sanguínea retrógrada contínua forneceu proteção adequada.
BACKGROUND: Several techniques and cardioplegic solutions have been used for heart preservation during transplant procedures. Unfortunately, there is a lack of ideal method for myocardial preservation in the clinical practice. The use of retrograde cardioplegia provides continuous infusion of cardioplegic solution during the graft implantation. This strategy may provide better initial recovery of the graft. The objective of this study is to describe the experience of a single center where all patients received the same solution for organ preservation and were subjected to continuous retrograde blood microcardioplegia during implantation of the graft and to evaluate factors associated to early and late mortality with this technique. METHODS: This is a retrospective, observational and descriptive study of a single center. RESULTS: During the study period were performed 35 heart transplants. Fifteen (42.9%) patients were in cardiogenic shock. The probability of survival was 74.8±7.8%, 60.4±11.3% and 15.1±13.4% at 1 year, 5 years and 10 years of follow-up, respectively. The median survival time was 96.6 months. CONCLUSION: The use of myocardial protection with retrograde cardioplegic solution may reduce the risks associated morbidity due to cold ischemia time during the heart transplant, and we suggest that this benefit may be even greater in cases of cold ischemia time longer ensuring protection to the myocardium.
BACKGROUND: Several techniques and cardioplegic solutions have been used for heart preservation during transplant procedures. Unfortunately, there is a lack of ideal method for myocardial preservation in the clinical practice. The use of retrograde cardioplegia provides continuous infusion of cardioplegic solution during the graft implantation. This strategy may provide better initial recovery of the graft. The objective of this study is to describe the experience of a single center where all patients received the same solution for organ preservation and were subjected to continuous retrograde blood microcardioplegia during implantation of the graft and to evaluate factors associated to early and late mortality with this technique. METHODS: This is a retrospective, observational and descriptive study of a single center. RESULTS: During the study period were performed 35 heart transplants. Fifteen (42.9%) patients were in cardiogenic shock. The probability of survival was 74.8±7.8%, 60.4±11.3% and 15.1±13.4% at 1 year, 5 years and 10 years of follow-up, respectively. The median survival time was 96.6 months. CONCLUSION: The use of myocardial protection with retrograde cardioplegic solution may reduce the risks associated morbidity due to cold ischemia time during the heart transplant, and we suggest that this benefit may be even greater in cases of cold ischemia time longer ensuring protection to the myocardium.
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lavagnoli2012brazilianfatores
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| Authors | ;Carlos Fernando Ramos Lavagnoli;Elaine Soraya Barbosa de Oliveira Severino;Karlos Alexandre de Souza Vilarinho;Lindemberg da Mota Silveira;Pedro Paulo Martins de Oliveira;Orlando Petrucci;Reinaldo Wilson Vieira;Domingo Marcolino Braile |
| Journal | 2017 international conference on information technology systems and innovation, icitsi 2017 - proceedings |
| Year | 2012 |
| DOI |
10.5935/1678-9741.20120061
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