the effect of low concentrations of ethanol on gastric adenocarcinoma cell lines
Clicks: 147
ID: 238714
2014
Article Quality & Performance Metrics
Overall Quality
Not rated
Combines reader engagement with the AI quality analysis. This
article has not been analysed, so there is no overall score —
reader engagement is measured and shown alongside.
Reader Engagement
Steady Performance
30.0
/100
147 views
44 readers
AI Quality Assessment
Not analyzed
Readership in this journal
SteadyRanked #102 of 117 articles by views in gastrointestinal endoscopy
Most read
Least read
Bar heights use a square-root scale.
Mint this article as an NFT
Not yet mintedCreate a permanent, verifiable on-chain record of this article on the Scimatic Network. The NFT is held in your Journament account, and you can withdraw it to your own wallet at any time.
5
SUSD
one-off · no wallet required
Abstract
Chronic alcohol consumption has been identified as a significant risk factor
for cancer in humans. The aim of the study was to analyze the influence of
low concentrations of ethanol on gastric adenocarcinoma cell viability,
apoptosis, and changes in the expression of alcohol dehydrogenase with
ethanol treatment. Gastric adenocarcinoma cell lines (MGC803, MGC823 and
SGC7901) were treated with different concentrations of ethanol (0.03125%,
0.0625%, 0.125%, 0.25%, 0.5%, 1%, 2%, and 4%). An MTT
(3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) assay and flow
cytometry were used to analyze the effect of ethanol treatment on cell
viability and apoptosis. Western blotting was used to analyze the expression
of alcohol dehydrogenase in gastric carcinoma cells. Ethanol treatment
inhibited cell proliferation in gastric adenocarcinoma cell lines in a
significant dose-dependent manner. Ethanol was also able to induce the
apoptosis of gastric adenocarcinoma cells in a dose-dependent manner. Alcohol
dehydrogenase activity of gastric adenocarcinoma cells increased with the
increase in the concentration of ethanol. Ethanol inhibited cell viability
and growth of gastric adenocarcinoma cell lines. Low concentrations of
ethanol also induced apoptosis and increased the expression of alcohol
dehydrogenase of the gastric adenocarcinoma cell lines.
| Reference Key |
lingjiao2014archivesthe
Use this key to autocite in the manuscript while using
SciMatic Manuscript Manager or Thesis Manager
|
|---|---|
| Authors | ;Wu Lingjiao;Chen Shaohua;Zhang Yu;Pan Hongming |
| Journal | gastrointestinal endoscopy |
| Year | 2014 |
| DOI |
10.2298/ABS1401317W
|
| URL | |
| Keywords |
Citations
No citations found. To add a citation, contact the admin at info@scimatic.org
Comments
No comments yet. Be the first to comment on this article.