effect of inhalant combined with dingchuan zhike decoction therapy on the airway remodeling, inflammation and parc/ccl- 18 pathways in patients with cough variant asthma
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2017
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Abstract
Objective: To study the effect of inhalant combined with Dingchuan Zhike decoction therapy
on the airway remodeling, inflammation and PARC/CCL-18 pathways in patients with cough
variant asthma. Methods: A total of 60 patients with cough variant asthma who were treated
in our hospital between January 2014 and May 2016 were collected and divided into the
control group (n=30) who received conventional inhalant treatment and the observation group
(n=30) who received inhalant combined with Dingchuan Zhike decoction treatment according
to single-blind randomized controlled method, and the treatment lasted for 6 months. Before
treatment and after 6 months of treatment, high-resolution CT was used to determine the
airway remodeling index levels, RIA method was used to detect the peripheral blood airway
remodeling index contents, and enzyme-linked immunosorbent assay (ELISA) was used to
detect the contents of inflammatory mediators in induced sputum and the PARC/CCL-18 in
serum. Results: Before treatment, the differences in the airway remodeling degree as well as
the contents of inflammatory mediators and PARC/CCL-18 were not statistically significant
between the two groups. After 6 months of treatment, CT airway remodeling indexes LA and
TA levels of observation group were higher than those of control group while WA level was
lower than that of control group, and peripheral blood airway remodeling indexes CTGF, YKL-
39, MMP-9 and TIMP-1 contents were lower tha=n those of control group; inflammatory
mediators IL-5, IL-6 and IL-8 contents in induced sputum of observation group were lower
than those of control group, and serum PARC/CCL-18 content was lower than that of control
group. Conclusion: Inhalant combined with Dingchuan Zhike decoction can inhibit the airway
remodeling and reduce the airway inflammation in patients with cough variant asthma.
| Reference Key |
han12017journaleffect
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|---|---|
| Authors | ;Ben Han1;Zi-Yan Huang2 |
| Journal | journal of communications |
| Year | 2017 |
| DOI |
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| URL | |
| Keywords | Keywords not found |
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