o transplante de medula óssea na leucemia mielóide aguda: análise de 80 pacientes transplantados no complexo do hospital das clínicas da faculdade de medicina da universidade de são paulo the allogeneic and autologous bone marrow transplantation in acute myeloid leukemia: analysis of 80 patients - bone marrow transplantation service - hospital das clínicas of the medical school, university of são paulo
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Abstract
The patients records of eighty consecutive patients with acute myeloid leukemia (AML) submitted to allogeneic (allo BMT) and autologous (auto BMT) bone marrow transplantation (BMT) between 1989 and 2001 were assessed. Forty percent were alive in the end of the study; 37.9% of allogeneic patients and 45.4% of autologous. Factors such as gender, the French-American-British AML classification, induction treatment, number of infused cells and the conditioning regiment did not have any impact in survival. Patients with AML from M1 to M4, and who were consolidated with high doses of arabinoside had better a survival rate (p=0.0148). Patients in their first complete remission also had better survival both with allogeneic and autologous BMT, with respective survival rates of 52.6% and 69.2%. Acute graft-versus-host disease (GvHD) had an impact when it was compared the absence, grade I/II with III/IV giving a p-value of 0.0285. Infection was the most frequent cause of death in allogeneic BMT. In autologous BMT relapse was the principal cause of death. Toxicity related to the procedure occurred in 38.9% of patients who died in allogeneic BMT and 16.7% in autologous BMT. In univariant Cox analyses for prognostic factors, the disease status and acute GvHD were significant, but this significance was lost in the multiple variant analyses (p-value = 0.069).
| Reference Key |
bueno2004revistao
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| Authors | ;Nadjanara D. Bueno;Rosaura Saboya;Maria Cristina Martins;Roberto L. Silva;Dalton A. F. Chamone;Isamara F. Rocha;Daniel Sturaro;Frederico L. Dulley |
| Journal | journal of computational and graphical statistics : a joint publication of american statistical association, institute of mathematical statistics, interface foundation of north america |
| Year | 2004 |
| DOI |
10.1590/S1516-84842004000200004
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| URL | |
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