histamine h3 receptor inverse agonists on cognitive and motor processes: relevance to alzheimer’s disease, adhd, schizophrenia and drug abuse

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ID: 236901
2012
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Abstract
Histamine H3 receptor antagonists/ inverse agonists possess potential to treat diverse disease states of the central nervous system (CNS). Cognitive dysfunction and motor impairments are the hallmark of multifarious neurodegenerative and/or psychiatric disorders. This review presents the various neurobiological/ neurochemical evidences available so far following H3 receptor inverse agonists/ antagonists in the pathophysiology of Alzheimer’s disease (AD), attention-deficit hyperactivity disorder (ADHD), schizophrenia and drug abuse each of which is accompanied by deficits of some aspects of cognitive and/or motor functions. Whether the H3 receptor inverse agonism modulates the neurochemical basis underlying the disease condition or affects only the cognitive/motor component of the disease process is discussed with the aim to provide a rationale for their use in diverse disease states that are interlinked and are accompanied by some common motor, cognitive and attentional deficits.
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evohora2012frontiershistamine Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Divya eVohora;Malay eBhowmik
Journal Vacuum
Year 2012
DOI
10.3389/fnsys.2012.00072
URL
http://journal.frontiersin.org/Journal/10.3389/fnsys.2012.00072/full
Keywords
cognition schizophrenia adhd locomotor activity alzheimer's disease neuropsychiatry biological psychiatry drug abuseneurosciences

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