histamine h3 receptor inverse agonists on cognitive and motor processes: relevance to alzheimer’s disease, adhd, schizophrenia and drug abuse

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ID: 236901
2012
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Abstract
Histamine H3 receptor antagonists/ inverse agonists possess potential to treat diverse disease states of the central nervous system (CNS). Cognitive dysfunction and motor impairments are the hallmark of multifarious neurodegenerative and/or psychiatric disorders. This review presents the various neurobiological/ neurochemical evidences available so far following H3 receptor inverse agonists/ antagonists in the pathophysiology of Alzheimer’s disease (AD), attention-deficit hyperactivity disorder (ADHD), schizophrenia and drug abuse each of which is accompanied by deficits of some aspects of cognitive and/or motor functions. Whether the H3 receptor inverse agonism modulates the neurochemical basis underlying the disease condition or affects only the cognitive/motor component of the disease process is discussed with the aim to provide a rationale for their use in diverse disease states that are interlinked and are accompanied by some common motor, cognitive and attentional deficits.
Reference Key
evohora2012frontiershistamine Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Divya eVohora;Malay eBhowmik
Journal Vacuum
Year 2012
DOI
10.3389/fnsys.2012.00072
URL
http://journal.frontiersin.org/Journal/10.3389/fnsys.2012.00072/full
Keywords
cognition schizophrenia adhd locomotor activity alzheimer's disease neuropsychiatry biological psychiatry drug abuseneurosciences

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