antioxidant capacity and genoprotective effect of ethanol fruit extract from detarium microcarpum guill. and perr. (caesalpiniaceae)

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ID: 236487
2017
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Abstract
Objective: To evidence the ability of ethanol fruit extract from Detarium microcarpum (D. microcarpum) to preserve DNA integrity against oxidative genomic damage. Methods: Ethanol extract from D. microcarpum fruit pulp was analyzed for its antioxidant capacity using ferric reducing antioxidant power, 2,2-diphenyl-1-picrylhydrazyl, 2,2′-azinobis-3-ethyl-ethylbenzothiazoline-6-sulphonate, superoxide anion, deoxyribose degradation and lipid peroxidation models. The genoprotective activity was assessed ex vivo by comet assay, on liver cells of NMRI female mice using cyclophosphamide (CP) as genotoxic agent. Results: Ethanol extract from D. microcarpum fruit pulp exhibited interesting antioxidant activity in 2,2-diphenyl-1-picrylhydrazyl, deoxyribose degradation and lipid peroxidation assays. The extract did not present any genotoxic effect but protected DNA against CP-induced damages with a dose-dependent manner. The genoprotective effect observed was related to the antioxidant molecules of the fruit that scavenged the hydroxyl radical (generated by the metabolism of CP) as well as the peroxyl and alkoxyl radicals issued from lipid peroxidation. Other mechanisms such as inactivation of CP metabolism to genotoxic end products, induction of the expression of antioxidant and DNA repair enzymes have been discussed. Conclusions: Our results suggest that the wild edible fruit from D. microcarpum could be beneficial on consumer's health by its antioxidant and genoprotective effects, particularly during chemotherapies exhibiting genotoxic effects like CP in cancer treatment.
Reference Key
rouamba2017asianantioxidant Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Ablassé Rouamba;Maurice Ouedraogo;Martin Kiendrebeogo
Journal Organic letters
Year 2017
DOI
10.1016/j.apjtb.2016.10.009
URL
http://www.sciencedirect.com/science/article/pii/S2221169116304725
Keywords
antioxidant activity comet assay tropical medicinebiology (general) genoprotectionarctic medicine

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