lack of association of the polymorphisms il-17a (−197g/a) and il-17f (+7488a/g) with multibacillary leprosy in mexican patients

Klicks: 197
ID: 236148
2014
Kostenloses PDF
Artikelqualität & Leistungskennzahlen
Gesamtqualität
Not rated
Combines reader engagement with the AI quality analysis. This article has not been analysed, so there is no overall score — reader engagement is measured and shown alongside.
KI-Qualitätsbewertung
Nicht analysiert
Readership in this journal
Popular

Ranked #25 of 49 articles by views in balıkesir medical journal

Most read Least read

Bar heights use a square-root scale.

Mint this article as an NFT
Not yet minted

Create a permanent, verifiable on-chain record of this article on the Scimatic Network. The NFT is held in your Journament account, and you can withdraw it to your own wallet at any time.

5 SUSD one-off · no wallet required
Sign in to mint
Abstract
Background. Leprosy is a chronic infectious disease caused by the intracellular acid-fast bacilli Mycobacterium leprae; it has been determined that genetic factors of the host play an important role in the disease susceptibility. Thus, in this case-control study, we evaluated the possible association between the IL-17A G-197A (rs227593) and IL-17F A7488G (His161Arg, rs763780) gene SNPs and susceptibility to leprosy disease in Mexican population. Methods. Seventy-five leprosy patients and sixty-nine control subjects were included. Both SNPs were genotyped with the polymerase chain reaction-restriction fragment length polymorphism technique. Results. We found nonsignificant differences in genotype and allele frequencies related to IL-17A G-197A (rs227593) and IL-17F A7488G (His161Arg, rs763780) gene SNPs in MB as well as subclinical forms of leprosy disease versus healthy individuals. Conclusions. Since the sample size is not large enough, it is difficult to sustain an association of susceptibility to leprosy with genotypes or allele frequencies of IL-17A G-197A (rs227593) and IL-17F A7488G (His161Arg, rs763780), suggesting that IL-17 polymorphisms have no significant role in the genetic susceptibility to development of this disease in the Mexican Mestizo population.
Referenzschlüssel
escamilla-tilch2014internationallack Verwenden Sie diesen Schlüssel zum automatischen Zitieren im Manuskript bei Verwendung von SciMatic Manuscript Manager oder Thesis Manager
Autoren Mónica Escamilla-Tilch, Iris Estrada-García, Julio Granados, Roberto Arenas-Guzmán, Rosalio Ramos-Payan, Thalía Gabriela Pérez-Suárez, Ma. Isabel Salazar, Riky Luis Pérez-Lucas, Sergio Estrada-Parra, Nora Magdalena Torres-Carrillo
Are you one of these authors? Claim your profile
Zeitschrift balıkesir medical journal
Jahr 2014
DOI
10.1155/2014/920491
URL
http://dx.doi.org/10.1155/2014/920491
Schlüsselwörter
genetics

Zitationen

Keine Zitationen gefunden. Um eine Zitation hinzuzufügen, kontaktieren Sie den Administrator unter info@scimatic.org

Kommentare

Noch keine Kommentare. Seien Sie der Erste, der diesen Artikel kommentiert.