the tumor microenvironment: a pitch for multiple players

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ID: 235323
2013
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Abstract
The cancer microenvironment may be conceptually regarded as a pitch where the main players are resident and non-resident cellular components, each covering a defined role and interconnected by a complex network of soluble mediators. The crosstalk between these cells and the tumor cells within this environment crucially determines the fate of tumor progression. Immune cells that infiltrate the tumor bed are transported there by blood circulation and exert a variety of effects, either counteracting or favouring tumor outgrowth. Here, we review and discuss the multiple populations composing the tumor bed, with special focus on immune cells subsets that positively or negatively dictate neoplastic progression. In this scenario, the contribution of cancer stem cells within the tumor microenvironment will also be discussed. Finally, we illustrate recent advances on new integrated approaches to investigate the tumor microenvironment in vitro.
Reference Key
eschiavoni2013frontiersthe Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Giovanna eSchiavoni;Lucia eGabriele;Fabrizio eMattei
Journal international journal of heat and technology
Year 2013
DOI
10.3389/fonc.2013.00090
URL
http://journal.frontiersin.org/Journal/10.3389/fonc.2013.00090/full
Keywords
tumor microenvironment mesenchymal stromal cells macrophages nk cells dendritic cells Oncology including cancer and carcinogens tumors t lymphocytesneoplasms

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