liposome encapsulation of doxorubicin and celecoxib in combination inhibits progression of human skin cancer cells
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ID: 235116
2018
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Abstract
Sanjay Singh Institute of Life Sciences, School of Science and Technology, Ahmedabad University, Ahmedabad, Gujarat, India Abstract: Therapeutic agents aimed at inhibiting a single molecular target have not been successful in cancer therapy, but rather they impart resistance. However, multi-target inhibitors have shown promising results in circumventing the development of resistance and inducing apoptosis in cancer cells/tissues. In this study, we encapsulated doxorubicin and celecoxib in a single liposome at a ratio of 1:10. These dual drug-encapsulated liposomes showed excellent anticancer activity compared to individually encapsulated liposomes. The expression of key proteins such as AKT and COX-2 was suppressed, which suggests that doxorubicin and celecoxib synergistically inhibit multiple key signaling pathways. Keywords: drug delivery, nanoliposomes, nanomedicines, cancer nanotechnology
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s2018internationalliposome
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| Authors | ;Singh S |
| Journal | nonlinear analysis: real world applications |
| Year | 2018 |
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