comparative study between endoscopic ultrasongraphy-assisted endoscopic mucosal resection and routine endoscopic mucosal resection treatment of esophageal precancerous lesions

Objective: To compare the trauma between endoscopic ultrasongraphy-assisted endoscopic mucosal resection and routine endoscopic mucosal resection treatment of esophageal precancerous lesions. Methods: A total of 59 patients with esophageal precancerous lesions who received endoscopic mucosal resection in our hospital between May 2013 and October 2016 were selected and divided into endoscope group and routine group who received endoscopic ultrasongraphy-assisted endoscopic mucosal resection and routine endoscopic mucosal resection respectively. Serum was collected immediately after operation to determine the content of stress-related molecules, tumor markers and proliferation-related molecules, and tumor tissue was collected to determine the expression of proliferation-related molecules. Results: Immediately after operation, renin, angiotensin II, aldosterone, epinephrine, norepinephrine, Cyfra21-1, SCC-Ag, TSGF, DDK-1, MACC1, c-met, CyclinB1, CDK1, Survivin and Bcl-2 content in serum of ultrasound group were significantly lower than those of normal group while MACC1, c-met, CyclinB1, CDK1, Survivin and Bcl-2 content in tumor tissue were not significantly different from those of normal group. Conclusions: The trauma of endoscopic ultrasongraphy-assisted endoscopic mucosal resection treatment of esophageal precancerous lesions is lower than that of routine endoscopic mucosal resection, the postoperative stress response is weaker and the leakage of tumor markers and proliferationrelated molecules in the tissue is fewer.