the relationship between natriuretic peptide precursor a gene t2238c polymorphism and hypertension: a meta-analysis
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2011
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Abstract
Single studies attempting to associate ANP gene T2238C (rs5065) polymorphism with hypertension have so far reported inconclusive results. We therefore aimed to evaluate this association via a meta-analysis. Data on 7 studies with a total of 4068 subjects were available and analyzed using the random-effects model with assessment of heterogeneity and publication bias. Overall comparison of 2238C with 2238T yielded a 23% reduced, albeit nonsignificant, risk for hypertension (95% CI: 0.38–1.59; P=.485), while accompanying significant heterogeneity (I2=88.3%) and publication bias (P=.051). Subgroup analysis by study design demonstrated opposite associations between population-based (OR=0.33; 95% CI: 0.13–0.80; P=.015) and hospital-based studies (OR=1.15; 95% CI: 0.79–1.68; P=.454). Further meta-regression analysis exclusively indicated the significant influence of study design (P=.042) on heterogeneity. Taken together, these findings support the notion that carriers of 2238C allele were at moderate decreased risk of developing hypertension, whereas study design was identified as a potentially significant source of between-study heterogeneity.
| Reference Key |
niu2011internationalthe
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| Authors | ;Wenquan Niu |
| Journal | molecular biology and evolution |
| Year | 2011 |
| DOI |
10.4061/2011/653698
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