the close interconnection between mitochondrial dynamics and mitophagy in cancer

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2017
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Abstract
Recent decades have revealed the shape changes of mitochondria and their regulators to be main players in a plethora of physiological cell processes. Mitochondria are extremely dynamic organelles whose highly controlled morphological changes respond to specific and diverse pathophysiological needs. Thus, their qualitative control is crucial for the determination of cell function and fate. Moreover, ever-new metabolic changes, mainly attributable to mitochondrial (dys)functions, are strongly connected to cancer and its microenvironment. For this reason, the aspects controlling mitochondria activity and status are in the oncological spotlight. In this review, we elucidate the most intriguing discoveries related to two apparently independent but strictly interconnected processes crucial for the organelle functionality and fate, mitochondrial dynamics, and mitophagy. We will mostly focus on their metabolic interconnections and regulations that can causally foster a tumoral context.
Reference Key
campello2017frontiersthe Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Silvia Campello;Silvia Campello;Matteo Bordi;Francesca Nazio
Journal international journal of heat and technology
Year 2017
DOI
10.3389/fonc.2017.00081
URL
http://journal.frontiersin.org/article/10.3389/fonc.2017.00081/full
Keywords
Cancer autophagy mitophagy mitochondrial dynamics Oncology including cancer and carcinogens tumors

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