comparison of polymethylmethacrylate (pmma), native calcium sulfate, and high porous calcium sulfate beads as gentamicin carriers and osteoblast attachment

Clicks: 348
ID: 232021
2013
Free PDF
Article Quality & Performance Metrics
Overall Quality
Not rated
Combines reader engagement with the AI quality analysis. This article has not been analysed, so there is no overall score — reader engagement is measured and shown alongside.
AI Quality Assessment
Not analyzed
Readership in this journal
Emerging

Ranked #5 of 95 articles by views in ferroelectrics

Most read Least read

Bar heights use a square-root scale.

Mint this article as an NFT
Not yet minted

Create a permanent, verifiable on-chain record of this article on the Scimatic Network. The NFT is held in your Journament account, and you can withdraw it to your own wallet at any time.

5 SUSD one-off · no wallet required
Sign in to mint
Abstract
Calcium sulfate, a bioresorbable material, has been used as a bone substitute material and antibiotic vehicle. The increasing porosity of calcium sulfate beads might improve drug delivery capacity as well as enhance the antibiotic elution property. High porous calcium sulfate (HPCS) beads were fabricated using a salt leaching technique as a new bead type for antibiotic delivery system. Gentamicin-based antibiotic beads were conducted by impregnating gentamicin (3.8% w/w) with polymethylmethacrylate (PMMA), or coating of PMMA, native calcium sulfate (NCS), and HPCS with gentamicin solution. Physical properties, microstructure, and gentamicin elution from gentamicin-impregnated PMMA (GI-PMMA), gentamicincoated PMMA (G-PMMA), gentamicin-coated NCS (G-NCS), and gentamicin-coated HPCS (G-HPCS) were compared. The osteoblast attachment revealed that PMMA, NCS, and HPCS beads were not toxic to h-OBs after co-incubation for sevendays. Furthermore, more h-OBs attachment appeared in HPCS beads compared to PMMA and NCS beads after co-culture for 7 days. Eluted gentamicin from G-NCS and G-HPCS beads were greater than those from GI-PMMA and G-PMMA beads during the experimental period. All types of beads were able to elute gentamicin for 10 days except G-PMMA, which released gentamicin only for four days. The highest to lowest total concentrations of eluted gentamicin were from G-NCS, G-HPCS,G-PMMA, and GI-PMMA, respectively. These results suggested that the HPCS beads improved local antibiotic delivery and improved h-OBs attachment.
Reference Key
thitiyanaporn2013songklanakarincomparison Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Chaiyakorn Thitiyanaporn;Naris Thengchaisri;Pareeya Udomkusonsri
Journal ferroelectrics
Year 2013
DOI
DOI not found
URL
http://rdo.psu.ac.th/sjstweb/journal/35-3/35-3-293.pdf
Keywords
porosity salt leaching

Citations

No citations found. To add a citation, contact the admin at info@scimatic.org

Comments

No comments yet. Be the first to comment on this article.