Neudesin is involved in anxiety behavior: structural and neurochemical correlates

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ID: 23167
2013
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Abstract
Neudesin (also known as neuron derived neurotrophic factor, Nenf) is a scarcely studied putative non-canonical neurotrophic factor. In order to understand its function in the brain, we performed an extensive behavioral characterization (motor, emotional and cognitive dimensions) of neudesin-null mice. The absence of neudesin leads to an anxious-like behavior as assessed in the elevated plus maze, light/dark box and novelty suppressed feeding tests, but not in the acoustic startle test. This anxious phenotype is associated with reduced dopaminergic input and impoverished dendritic arborizations in the dentate gyrus granule neurons of the ventral hippocampus. Interestingly, shorter dendrites are also observed in the bed nucleus of the stria terminalis (BNST) of neudesin-null mice. These findings lead us to suggest that neudesin is a novel relevant player in the maintenance of the anxiety circuitry.
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enovais2013neudesinfrontiers Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors eNovais, Ashley;eNovais, Ashley;Ferreira, Ana Catarina;Ferreira, Ana Catarina;eMarques, Fernanda;eMarques, Fernanda;Pêgo, José M;Pêgo, José M;Cerqueira, João J;Cerqueira, João J;eDavid-Pereira, Ana;eDavid-Pereira, Ana;Campos, Filipa L;Campos, Filipa L;eDalla, Christina;eKokras, Nikolaos;eSousa, Nuno;eSousa, Nuno;Palha, Joana A;Palha, Joana A;Sousa, Joao C;Sousa, Joao C;
Journal frontiers in behavioral neuroscience
Year 2013
DOI
DOI not found
URL
http://journal.frontiersin.org/Journal/10.3389/fnbeh.2013.00119/full
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