study and analysis of oxidative stress and cell apoptosis in retinal tissue of diabetic model rats after total flavonoids of onion treatment

Clicks: 161
ID: 231351
2017
Free PDF
Article Quality & Performance Metrics
Overall Quality
Not rated
Combines reader engagement with the AI quality analysis. This article has not been analysed, so there is no overall score — reader engagement is measured and shown alongside.
AI Quality Assessment
Not analyzed
Readership in this journal
Emerging

Ranked #58 of 96 articles by views in journal of communications

Most read Least read

Bar heights use a square-root scale.

Mint this article as an NFT
Not yet minted

Create a permanent, verifiable on-chain record of this article on the Scimatic Network. The NFT is held in your Journament account, and you can withdraw it to your own wallet at any time.

5 SUSD one-off · no wallet required
Sign in to mint
Abstract
Objective: To study the effect of total flavonoids of onion treatment on oxidative stress and cell apoptosis in the retinal tissue of diabetic model rats. Methods: Male SD rats were selected as experimental animals and randomly divided into control group, diabetes group, lowdosage total flavonoids group (total flavonoids L group) and high-dose total flavonoids (total flavonoids H group), intraperitoneal injection of streptozotocin was adopted to make diabetes model, and the total flavonoids L group and H group received lavage of 100 mg/kg and 200 mg/kg total flavonoids of onion for intervention. After 8 weeks of intervention, retinal tissue was collected and the degree of oxidative stress and cell apoptosis were determined. Results: P2X7, ROS, ﹣OH, O2﹣, H2O2, FADD, p-JNK, caspase-8 and caspase-3 levels in retinal tissue of diabetes group were significantly higher than those of control group while Mn-SOD, CAT, GSH, AsA, NGF, BDNF and CNTF levels were significantly lower than those of control group; P2X7, ROS, ﹣OH, O2﹣, H2O2, FADD, p-JNK, caspase-8 and caspase-3 levels in retinal tissue of total flavonoids L group and total flavonoids H group were significantly lower than those of diabetes group while Mn-SOD, CAT, GSH, AsA, NGF, BDNF and CNTF levels were significantly higher than those of diabetes group; P2X7, ROS, ﹣OH, O2﹣, H2O2, FADD, p-JNK, caspase-8 and caspase-3 levels in retinal tissue of total flavonoids H group were significantly lower than those of total flavonoids L group while Mn-SOD, CAT, GSH, AsA, NGF, BDNF and CNTF levels were significantly higher than those of total flavonoids L group. Conclusion: Total flavonoids of onion have inhibiting effect on the oxidative stress and cell apoptosis in retinal tissue of diabetic model rats.
Reference Key
shi2017journalstudy Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Wei Shi
Journal journal of communications
Year 2017
DOI
DOI not found
URL
http://www.hnykdxxb.com/PDF/201709/1.pdf
Keywords
Diabetic retinopathy oxidative stress

Citations

No citations found. To add a citation, contact the admin at info@scimatic.org

Comments

No comments yet. Be the first to comment on this article.