evaluation of the anti-inflammatory, antinociceptive and antipyretic activities of the extracts from smilax corbularia kunth rhizomes in mice and rats (in vivo)

The effects of either ethanol or aqueous extract from rhizomes of Smilax corbularia Kunth (S. corbularia) on anti-inflammatory activity in carrageenin-induced edema in rats, antinociceptive activity using writhing, hot plate and formalin tests in mice and the antipyretic activity in yeast-induced fever were examined. Oral administration of the ethanol extract of S. corbularia rhizomes significantly suppressed the paw edema induced by carrageenin in rats while the aqueous extract had no effect. Neither the ethanol extract nor aqueous extract significantly affected the antinociceptive tests in mice and yeast-induced fever in rats. These results suggest that the ethanol extract of S. corbularia rhizomes possess anti-inflammatory activity, and that its actions on the inflammation may be different from those of aspirin.