the fas/cd95 receptor regulates the death of autoreactive b cells and the selection of antigen-specific b cells

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ID: 230522
2012
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Abstract
Cell death receptors have crucial roles in the regulation of immune responses. Here we review recent in vivo data confirming that the Fas death receptor (TNFSR6) on B cells is important for the regulation of autoimmunity since the impairment of only Fas function on B cells results in uncontrolled autoantibody production and autoimmunity. Fas plays a role in the elimination of the non-specific and auto-reactive B cells in germinal center, while during the selection of antigen specific B cells different escape signals ensure the resistance to Fas-mediated apoptosis. Antigen specific survival such as BCR or MHCII signal or coreceptors (CD19) cooperating with BCR inhibits the formation of death inducing signaling complex. Antigen-specific survival can be reinforced by antigen-independent signals of IL4 or CD40 overproducing the anti-apoptotic members of the Bcl-2 family proteins.
Reference Key
ehueber2012frontiersthe Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Anne-Odile eHUEBER;Gabor eKONCZ
Journal sudebno-meditsinskaia ekspertiza
Year 2012
DOI
10.3389/fimmu.2012.00207
URL
http://journal.frontiersin.org/Journal/10.3389/fimmu.2012.00207/full
Keywords
immunity b cells allergy

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