aurora a overexpression and pvhl reduced expression are correlated with a bad kidney cancer prognosis
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ID: 230238
2012
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Abstract
We investigate the expression and localization of the tumor suppressor protein pVHL as well as the oncoprotein Aurora A kinase in kidney cancer. Both Aurora A kinase and pVHL protein status were evaluated using immunohistochemistry. The Aurora A expression is correlated with the Fuhrman grade and the TNM stage, while the pVHL expression is correlated with the capsule rupture and the TNM stage. Aurora A kinase expression increases in malignant tissue comparing to the non-malignant one. And there is a decrease in pVHL expression from the adjacent healthy tissues to the tumor`s ones. The two kinds of opposite tumor profiles display significant distribution difference according to TNM stages. It could be proposed that the absence of Aurora A protein associated with a strong expression of pVHL in clear cells kidney carcinoma are of good prognosis for the disease.
| Reference Key |
ferchichi2012diseaseaurora
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|---|---|
| Authors | ;Imen Ferchichi;Nadia Kourda;Samia Sassi;Khaled Ben Romdhane;Sarra Balatgi;Jean Yves Cremet;Claude Prigent;Amel Benammar Elgaaied |
| Journal | international journal of psychology : journal international de psychologie |
| Year | 2012 |
| DOI |
10.3233/DMA-2012-00942
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| URL | |
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