the effects of b-cyclodextrin and ph on bifonazole hydrosolubility
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2004
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Abstract
The equlibria of bifonazole in saturated water solution within the pH range 4 to 10 [I = 0.1 mol/dm3 (NaCl); 25 ºC] were studied spectrophotometrically. Based on the equlibrium constants determined in a heterogeneous system, the acidity constant (pKa = 5.72) and solubility in water (S = 10-5.79 + 10-(pH + 0.07) were calculated. The influence of b-cyclodextrin on bifonazole solubility was examined in the presence of 10-3 and 10-4 mol/dm3 b-cyclodextrin. At pH values over 8, bifonazole solubility was two- and 13-fold increased in the presence of 10-4 and 10-3 mol/dm3 b-cyclodextrin, respectively, compared to its solubility in water. The ratio of bifonazole solubility in the presence of b-cyclodextrin and that in water decreased in parallel to the increase of acidity.
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| Authors | ;MIRA CAKAR;GORDANA POPOVIC |
| Journal | meditsinskaia radiologiia |
| Year | 2004 |
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