estudo comparativo da flarefotometria em pacientes com melanoma maligno e nevo de coróide comparative study of flare photometry in patients with choroidal malignant melanoma and choroidal nevus

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ID: 229823
2002
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Abstract
Introdução: Os tumores malignos intra-oculares estão associados com um aumento do "flare" na câmara anterior, causado por uma quebra na barreira hemato-aquosa, que pode ocorrer por vários mecanismos. Estudos utilizando a flarefotometria confirmam o aumento do "flare" em olhos com tumores intra-oculares malignos e benignos. Objetivo: Avaliar a flarefotometria como auxiliar no diagnóstico diferencial de melanoma maligno e nevo de coróide, comparando-se com olhos contralaterais normais. Métodos: Foram avaliados olhos com melanoma maligno e olhos com nevo de coróide diagnosticados por meio de oftalmoscopia indireta e/ou ultra-sonografia. Os olhos normais contralaterais foram utilizados como controles. A flarefotometria foi realizada em todos os pacientes, sob midríase bilateral, utilizando equipamento Laser Flare Meter (FC 500, Kowa). Foram aplicados os testes de Wilcoxon, Mann-Whitney, e Spearman para análise estatística. Resultados: A média da flarefotometria nos olhos com melanoma maligno de coróide foi 17,1 ph/ms e nos olhos normais contralaterais foi 4,06 ph/ms. Nos olhos com nevo de coróide o valor da flarefotometria foi 6,12 ph/ms e nos olhos contralaterais normais foi 4,47 ph/ms. O valor da flarefotometria foi maior nos olhos com melanoma maligno e nevo quando comparado com os olhos contralaterais normais (p<0,001 e p<0,01). Nos olhos com melanoma maligno o valor da flarefotometria foi significantemente maior que nos olhos com nevo de coróide (p<0,001). Foi observada correlação positiva entre a espessura do tumor e a flarefotometria (r=0,47). Conclusão: A flarefotometria é um exame útil no diagnóstico diferencial entre melanoma maligno e nevo de coróide.
Introduction: Malignant intraocular tumors are associated with an increase in the aqueous flare, caused by alterations of the blood-ocular barriers through various mechanisms. Several studies have demonstrated an ocular flare increase using flare photometry in eyes with benign and malignant tumors. Purpose: To evaluate flare photometry as an adjunct method in the differential diagnosis of choroidal malignant melanoma and choroidal nevus comparing to normal control eyes. Methods: Eyes with melanoma and nevus were diagnosed by indirect binocular ophthalmoscopy and/or ultrasound were evaluated. The fellow normal eyes were used as a control. In all subject and control eyes flare photometry was performed using the Laser Flare Meter (FC 500, Kowa), under mydriasis. Statistical analysis was done using the Wilcoxon, Mann-Whitney, and Spearman tests. Results: Thirty-one eyes with malignant melanoma and 18 eyes with nevus were evaluated. The flare photometry average in the eyes with malignant melanoma was 17.1 ph/ms and in the control fellow eyes it was 4.06 ph/ms. In eyes with choroidal nevus the flare photometry average was 6.12 ph/ms and in the control fellow eyes it was 4.47 ph/ms. The flare photometry was higher in eyes with malignant melanoma and nevus than in the fellow normal eyes (p<0.001 and p<0.01). Comparing the eyes with malignant melanoma and nevus, flare photometry was significantly higher in eyes with malignant melanoma (p<0.001). There was a positive correlation between the tumor thickness and flare photometry (r=0.47). Conclusion: Flare photometry is a helpful tool in the differential diagnosis of malignant melanoma and choroidal nevus.
Reference Key
ballalai2002arquivosestudo Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Priscilla Luppi Ballalai;Clélia Maria Erwenne;Martha Motono Chojniak
Journal introducing innodb cluster: learning the mysql high availability stack
Year 2002
DOI
10.1590/S0004-27492002000100006
URL
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-27492002000100006
Keywords
melanoma differential diagnosis comparative study estudo comparativo blood-aqueous barrierophthalmology

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