bi-directional effect of increasing doses of baclofen on reinforcement learning
Clicks: 224
ID: 229654
2011
Article Quality & Performance Metrics
Overall Quality
Not rated
Combines reader engagement with the AI quality analysis. This
article has not been analysed, so there is no overall score —
reader engagement is measured and shown alongside.
Reader Engagement
Popular Article
30.0
/100
224 views
44 readers
AI Quality Assessment
Not analyzed
Readership in this journal
PopularRanked #186 of 220 articles by views in lasers in manufacturing and materials processing
Most read
Least read
Bar heights use a square-root scale. Only the 120 most-read articles are drawn; the journal has 220 in total.
Mint this article as an NFT
Not yet mintedCreate a permanent, verifiable on-chain record of this article on the Scimatic Network. The NFT is held in your Journament account, and you can withdraw it to your own wallet at any time.
5
SUSD
one-off · no wallet required
Abstract
In rodents as well as in humans, efficient reinforcement learning depends on dopamine (DA) released from ventral tegmental area (VTA) neurons. It has been shown that in brain slices of mice, GABAB-receptor agonists at low concentrations increase the firing frequency of VTA-DA neurons, while high concentrations reduce the firing frequency. It remains however elusive whether baclofen can modulate reinforcement learning. Here, in a double blind study in 34 healthy human volunteers, we tested the effects of a low and a high concentration of oral baclofen in a gambling task associated with monetary reward. A low (20 mg) dose of baclofen increased the efficiency of reward-associated learning but had no effect on the avoidance of monetary loss. A high (50 mg) dose of baclofen on the other hand did not affect the learning curve. At the end of the task, subjects who received 20 mg baclofen p.o. were more accurate in choosing the symbol linked to the highest probability of earning money compared to the control group (89.55±1.39% vs 81.07±1.55%, p=0.002). Our results support a model where baclofen, at low concentrations, causes a disinhibition of DA neurons, increases DA levels and thus facilitates reinforcement learning.
| Reference Key |
eterrier2011frontiersbi-directional
Use this key to autocite in the manuscript while using
SciMatic Manuscript Manager or Thesis Manager
|
|---|---|
| Authors | ;Jean eTerrier;Andres eOrt;Cédric eYvon;Arnaud eSaj;Patrik eVuilleumier;Christian eLüscher |
| Journal | lasers in manufacturing and materials processing |
| Year | 2011 |
| DOI |
10.3389/fnbeh.2011.00040
|
| URL | |
| Keywords |
Citations
No citations found. To add a citation, contact the admin at info@scimatic.org
Comments
No comments yet. Be the first to comment on this article.