implications of mmp9 for blood brain barrier disruption and hemorrhagic transformation following ischemic stroke

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ID: 229625
2016
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Abstract
Numerous studies have documented increases in matrix metalloproteinases (MMPs), specifically MMP-9 levels following stroke, with such perturbations associated with disruption of the blood brain barrier (BBB), increased risk of hemorrhagic complications and worsened outcome. Despite this, controversy remains as to which cells release MMP-9 at the normal and pathological BBB, with even less clarity in the context of stroke. This may be further complicated by the influence of tissue plasminogen activator (tPA) treatment. The aim of the present review is to examine the relationship between neutrophils, MMP-9 and tPA following ischemic stroke to elucidate which cells are responsible for the increases in MMP-9 and resultant barrier changes and hemorrhage observed following stroke.
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turner2016frontiersimplications Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Renee Jade Turner;Frank R Sharp
Journal macromolecular bioscience
Year 2016
DOI
10.3389/fncel.2016.00056
URL
http://journal.frontiersin.org/Journal/10.3389/fncel.2016.00056/full
Keywords
blood-brain barrier neutrophils ischemic stroke cerebral edema tpa neuropsychiatry biological psychiatry

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