bone marrow stem cells and their role in angiogenesis células-tronco da medula óssea e seu papel na angiogênese

Clicks: 237
ID: 229619
2005
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Abstract
The degree of symptomatology of a patient with peripheral arterial disease dictates the kind of treatment. Despite the known therapies, some patients continue to have pain with ambulation, which affects their quality of life. The therapeutic implications of the angiogenic growth factors were identified by the pioneering studies of Folkman et al. 2 decades ago. Further investigations established the possibility of the use of formulations of recombinant angiogenic growth factors, with the objective of developing or increasing the network of collaterals in animal models of chronic myocardial or limb ischemia. Researches suggest that primitive stem cells with whole bone marrow possess greater functional plasticity, capable of contributing to regeneration of ischemic limb muscle and vascular endothelium by adult stem cells. Local autologous marrow stromal cells implantation induces a neovascular response resulting in a significant increase in blood flow to the ischemic limb. In this article we review the studies that have established how the implantation of bone marrow cells into ischemic limbs increases collateral vessel formation.
O nível de sintomatologia de um paciente com doença arterial periferal determina o tipo de tratamento. Apesar das terapias conhecidas, alguns pacientes continuam a ter dor com a deambulação, o que afeta sua qualidade de vida. As implicações terapêuticas dos fatores de crescimento angiogênicos foram identificadas por estudos pioneiros de Folkman et al. há 2 décadas. Investigações posteriores estabeleceram a possibilidade de utilizar formulações de fatores de crescimento angiogênico recombinantes, com o objetivo de desenvolver ou aumentar a rede de colaterais em modelos animais de isquemia crônica ou miocárdica. Pesquisas sugerem que células-tronco primitivas com medula óssea possuem maior funcionalidade plástica, capazes de contribuir com a regeneração de músculos isquêmicos e endotélio vascular por células-tronco adultas. O implante local e autólogo de células estromais da medula induz a uma resposta neovascular, resultando em um aumento significativo de fluxo sangüíneo no membro isquêmico. Neste artigo, revisamos os estudos que estabeleceram como o implante de células da medula óssea em membros isquêmicos aumenta a formação de vasos colaterais.
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reis2005jornalbone Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Paulo Eduardo Ocke Reis
Journal medecine et sante tropicales
Year 2005
DOI
10.1590/S1677-54492005000400012
URL
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1677-54492005000400012
Keywords
stem cells growth factor

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