Multi-ancestry study of blood lipid levels identifies four loci interacting with physical activity

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ID: 22847
2019
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Abstract
GWAS have identified more than 500 genetic loci associated with blood lipid levels. Here, the authors report a genome-wide analysis of interactions between genetic markers and physical activity, and find that physical activity modifies the effects of four genetic loci on HDL or LDL cholesterol.
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kilpelinen2019multiancestrynature Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Kilpeläinen, Tuomas O.;Bentley, Amy R.;Noordam, Raymond;Sung, Yun Ju;Schwander, Karen;Winkler, Thomas W.;Jakupović, Hermina;Chasman, Daniel I.;Manning, Alisa;Ntalla, Ioanna;Aschard, Hugues;Brown, Michael R.;Fuentes, Lisa de las;Franceschini, Nora;Guo, Xiuqing;Vojinovic, Dina;Aslibekyan, Stella;Feitosa, Mary F.;Kho, Minjung;Musani, Solomon K.;Richard, Melissa;Wang, Heming;Wang, Zhe;Bartz, Traci M.;Bielak, Lawrence F.;Campbell, Archie;Dorajoo, Rajkumar;Fisher, Virginia;Hartwig, Fernando P.;Horimoto, Andrea R. V. R.;Li, Changwei;Lohman, Kurt K.;Marten, Jonathan;Sim, Xueling;Smith, Albert V.;Tajuddin, Salman M.;Alver, Maris;Amini, Marzyeh;Boissel, Mathilde;Chai, Jin Fang;Chen, Xu;Divers, Jasmin;Evangelou, Evangelos;Gao, Chuan;Graff, Mariaelisa;Harris, Sarah E.;He, Meian;Hsu, Fang-Chi;Jackson, Anne U.;Zhao, Jing Hua;Kraja, Aldi T.;Kühnel, Brigitte;Laguzzi, Federica;Lyytikäinen, Leo-Pekka;Nolte, Ilja M.;Rauramaa, Rainer;Riaz, Muhammad;Robino, Antonietta;Rueedi, Rico;Stringham, Heather M.;Takeuchi, Fumihiko;Most, Peter J. van der;Varga, Tibor V.;Verweij, Niek;Ware, Erin B.;Wen, Wanqing;Li, Xiaoyin;Yanek, Lisa R.;Amin, Najaf;Arnett, Donna K.;Boerwinkle, Eric;Brumat, Marco;Cade, Brian;Canouil, Mickaël;Chen, Yii-Der Ida;Concas, Maria Pina;Connell, John;Mutsert, Renée de;Silva, H. Janaka de;Vries, Paul S. de;Demirkan, Ayşe;Ding, Jingzhong;Eaton, Charles B.;Faul, Jessica D.;Friedlander, Yechiel;Gabriel, Kelley P.;Ghanbari, Mohsen;Giulianini, Franco;Gu, Chi Charles;Gu, Dongfeng;Harris, Tamara B.;He, Jiang;Heikkinen, Sami;Heng, Chew-Kiat;Hunt, Steven C.;Ikram, M. Arfan;Jonas, Jost B.;Koh, Woon-Puay;Komulainen, Pirjo;Krieger, Jose E.;Kritchevsky, Stephen B.;Kutalik, Zoltán;Kuusisto, Johanna;Langefeld, Carl D.;Langenberg, Claudia;Launer, Lenore J.;Leander, Karin;Lemaitre, Rozenn N.;Lewis, Cora E.;Liang, Jingjing;Study, Lifelines Cohort;Liu, Jianjun;Mägi, Reedik;Manichaikul, Ani;Meitinger, Thomas;Metspalu, Andres;Milaneschi, Yuri;Mohlke, Karen L.;Mosley, Thomas H.;Murray, Alison D.;Nalls, Mike A.;Nang, Ei-Ei Khaing;Nelson, Christopher P.;Nona, Sotoodehnia;Norris, Jill M.;Nwuba, Chiamaka Vivian;O’Connell, Jeff;Palmer, Nicholette D.;Papanicolau, George J.;Pazoki, Raha;Pedersen, Nancy L.;Peters, Annette;Peyser, Patricia A.;Polasek, Ozren;Porteous, David J.;Poveda, Alaitz;Raitakari, Olli T.;Rich, Stephen S.;Risch, Neil;Robinson, Jennifer G.;Rose, Lynda M.;Rudan, Igor;Schreiner, Pamela J.;Scott, Robert A.;Sidney, Stephen S.;Sims, Mario;Smith, Jennifer A.;Snieder, Harold;Sofer, Tamar;Starr, John M.;Sternfeld, Barbara;Strauch, Konstantin;Tang, Hua;Taylor, Kent D.;Tsai, Michael Y.;Tuomilehto, Jaakko;Uitterlinden, André G.;Ende, M. Yldau van der;Heemst, Diana van;Voortman, Trudy;Waldenberger, Melanie;Wennberg, Patrik;Wilson, Gregory;Xiang, Yong-Bing;Yao, Jie;Yu, Caizheng;Yuan, Jian-Min;Zhao, Wei;Zonderman, Alan B.;Becker, Diane M.;Boehnke, Michael;Bowden, Donald W.;Faire, Ulf de;Deary, Ian J.;Elliott, Paul;Esko, Tõnu;Freedman, Barry I.;Froguel, Philippe;Gasparini, Paolo;Gieger, Christian;Kato, Norihiro;Laakso, Markku;Lakka, Timo A.;Lehtimäki, Terho;Magnusson, Patrik K. E.;Oldehinkel, Albertine J.;Penninx, Brenda W. J. H.;Samani, Nilesh J.;Shu, Xiao-Ou;Harst, Pim van der;Vliet-Ostaptchouk, Jana V. Van;Vollenweider, Peter;Wagenknecht, Lynne E.;Wang, Ya X.;Wareham, Nicholas J.;Weir, David R.;Wu, Tangchun;Zheng, Wei;Zhu, Xiaofeng;Evans, Michele K.;Franks, Paul W.;Gudnason, Vilmundur;Hayward, Caroline;Horta, Bernardo L.;Kelly, Tanika N.;Liu, Yongmei;North, Kari E.;Pereira, Alexandre C.;Ridker, Paul M.;Tai, E. Shyong;Dam, Rob M. van;Fox, Ervin R.;Kardia, Sharon L. R.;Liu, Ching-Ti;Mook-Kanamori, Dennis O.;Province, Michael A.;Redline, Susan;Duijn, Cornelia M. van;Rotter, Jerome I.;Kooperberg, Charles B.;Gauderman, W. James;Psaty, Bruce M.;Rice, Kenneth;Munroe, Patricia B.;Fornage, Myriam;Cupples, L. Adrienne;Rotimi, Charles N.;Morrison, Alanna C.;Rao, Dabeeru C.;Loos, Ruth J. F.;
Journal Nature communications
Year 2019
DOI
DOI not found
URL
http://link.springer.com/article/10.1038/s41467-018-08008-w
Keywords Keywords not found

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