anti-ulcerative colitis activity of calotropis procera linn.
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ID: 228113
2018
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Abstract
The aim of the present study was to evaluate the anti-ulcerative colitis activity of Calotropis procera. Different extracts of the investigated plant were evaluated; total alcohol extract, polar extract and non-polar extract. All the investigated extracts at doses 200 &400 mg/kg possessed a dose-dependent anti-ulcerative colitis potential when administrated for 5 consecutive days after colitis induction by acetic acid in rats. They reduced different parameters of UC. Only polar extract at both doses (200, 400 mg/kg) was more effective than the standard drug Prednisolone (50 mg/kg), it produced percent protection of control colitis by 63.8% and78.4% respectively, while the standard drug Prednisolone produced 54.9% protection. The anti-ulcerative colitis activity may be attributed to the active principles i.e. flavonoids. Preliminary phytochemical screening showed that the plant contains flavonoids, unsaturated sterols and/or triterpenoides, cardiac glycosides, carbohydrates or glycosides, proteins and/or amino acids, tannins and coumarins. The total alcohol extract was safe up to 4000 mg/kg and there were no side effects reported on liver and kidney functions. Keywords: Calotropis procera, Anti-ulcerative colitis, Anti-inflammatory, Liver function, Kidney function, Phytochemical screening
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awaad2018saudianti-ulcerative
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| Authors | ;Amani A. Awaad;Haya F. Alkanhal;Reham M. El-Meligy;Ghada M. Zain;Vidya D. Sesh Adri;Dina A. Hassan;Saleh I. Alqasoumi |
| Journal | International journal for quality in health care : journal of the International Society for Quality in Health Care |
| Year | 2018 |
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