treatment resistance mechanisms of malignant glioma tumor stem cells

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ID: 228023
2011
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Abstract
Malignant gliomas are highly lethal because of their resistance to conventional treatments. Recent evidence suggests that a minor subpopulation of cells with stem cell properties reside within these tumors. These tumor stem cells are more resistant to radiation and chemotherapies than their counterpart differentiated tumor cells and may underlie the persistence and recurrence of tumors following treatment. The various mechanisms by which tumor stem cells avoid or repair the damaging effects of cancer therapies are discussed.
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schmalz2011cancerstreatment Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Philip G.R. Schmalz;John K. Park;Michael J. Shen
Journal The Journal of investigative dermatology
Year 2011
DOI
10.3390/cancers3010621
URL
http://www.mdpi.com/2072-6694/3/1/621/
Keywords
glioblastoma Chemotherapy malignant glioma Oncology including cancer and carcinogens tumors radiation therapyneoplasms

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