role of the polycystins in cell migration, polarity, and tissue morphogenesis

多囊蛋白在细胞迁移、极性和组织形态发生中的作用

Clicks: 307
ID: 227982
2015
Free PDF
Article Quality & Performance Metrics
Overall Quality
Not rated
Combines reader engagement with the AI quality analysis. This article has not been analysed, so there is no overall score — reader engagement is measured and shown alongside.
AI Quality Assessment
Not analyzed
Readership in this journal
Popular

Ranked #226 of 510 articles by views in Frontiers in psychology

Most read Least read

Bar heights use a square-root scale. Only the 120 most-read articles are drawn; the journal has 510 in total.

Mint this article as an NFT
Not yet minted

Create a permanent, verifiable on-chain record of this article on the Scimatic Network. The NFT is held in your Journament account, and you can withdraw it to your own wallet at any time.

5 SUSD one-off · no wallet required
Sign in to mint
Abstract
Cystic kidney diseases (CKD) is a class of disorders characterized by ciliary dysfunction and, therefore, belonging to the ciliopathies. The prototype CKD is autosomal dominant polycystic kidney disease (ADPKD), whose mutated genes encode for two membrane-bound proteins, polycystin-1 (PC-1) and polycystin-2 (PC-2), of unknown function. Recent studies on CKD-associated genes identified new mechanisms of morphogenesis that are central for establishment and maintenance of proper renal tubular diameter. During embryonic development in the mouse and lower vertebrates a convergent-extension (CE)-like mechanism based on planar cell polarity (PCP) and cellular intercalation is involved in “sculpting” the tubules into a narrow and elongated shape. Once the appropriate diameter is established, further elongation occurs through oriented cell division (OCD). The polycystins (PCs) regulate some of these essential processes. In this review we summarize recent work on the role of PCs in regulating cell migration, the cytoskeleton, and front-rear polarity. These important properties are essential for proper morphogenesis of the renal tubules and the lymphatic vessels. We highlight here several open questions and controversies. Finally, we try to outline some of the next steps required to study these processes and their relevance in physiological and pathological conditions.
囊性肾病（CKD）是一类以纤毛功能障碍为特征的疾病，因此归属于纤毛病。最具代表性的囊性肾病是常染色体显性多囊肾病（ADPKD），其突变基因编码两种功能尚不明确的膜结合蛋白——多囊蛋白-1（PC-1）和多囊蛋白-2（PC-2）。近期针对囊性肾病相关基因的研究揭示了新的形态发生机制，这些机制对建立和维持正常的肾小管管径至关重要。在小鼠和低等脊椎动物的胚胎发育过程中，一种基于平面细胞极性（PCP）和细胞插叠的类趋同延伸（CE）机制参与了将肾小管“塑造”为细长形态的过程。一旦确立了适宜的管径，小管的进一步伸长则通过定向细胞分裂（OCD）实现。多囊蛋白（PCs）调控着其中的部分关键过程。在本综述中，我们总结了近年来关于 PCs 在调控细胞迁移、细胞骨架以及前后极性中所起作用的研究进展。这些重要特性对于肾小管和淋巴管的正常形态发生必不可少。我们在此重点阐明了若干悬而未决的问题与争议。最后，我们尝试概述了进一步研究这些过程及其在生理和病理条件下相关性所需的后续工作方向。
Reference Key
nigro2015cellsrole Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Elisa Agnese Nigro;Maddalena Castelli;Alessandra Boletta
Journal Frontiers in psychology
Year 2015
DOI
10.3390/cells4040687
URL
http://www.mdpi.com/2073-4409/4/4/687
Keywords
cell migration cilia cell polarity

Citations

No citations found. To add a citation, contact the admin at info@scimatic.org

Comments

No comments yet. Be the first to comment on this article.