brain regions associated with the acquisition of conditioned place preference for cocaine versus social interaction

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ID: 227839
2012
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Abstract
Positive social interaction could play an essential role in switching the preference of the substance dependent individual away from drug related activities. We have previously shown that conditioned place preference (CPP) for cocaine at the dose of 15 mg/kg and CPP for four 15-min episodes of social interaction were equally strong when rats were concurrently conditioned for place preference by pairing cocaine with one compartment and social interaction with the other. The aim of the present study was to investigate the differential activation of brain regions related to the reward circuitry after acquisition/expression of cocaine CPP or social interaction CPP. Our findings indicate that cocaine CPP and social interaction CPP activated almost the same brain regions. However, the granular insular cortex and the dorsal part of the agranular insular cortex were more activated after cocaine CPP, whereas the prelimbic cortex and the core subregion of the nucleus accumbens were more activated after social interaction CPP. These results suggest that the insular cortex appears to be potently activated after drug conditioning learning while activation of the prelimbic cortex - nucleus accumbens core projection seems to be preferentially involved in the conditioning to non-drug stimuli such as social interaction.
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rawas2012frontiersbrain Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Rana eEl Rawas;Sabine eKlement;Kai eKummer;Michael eFritz;Michael eFritz;Georg eDechant;Alois eSaria;Gerald eZernig
Journal lasers in manufacturing and materials processing
Year 2012
DOI
10.3389/fnbeh.2012.00063
URL
http://journal.frontiersin.org/Journal/10.3389/fnbeh.2012.00063/full
Keywords
social interaction reward cocaine conditioned place preference neuropsychiatry biological psychiatry drug abuseneurosciences

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