evidence for existence of thyroid hormone inducible semicarbazide-sensitive amine oxidase (ssao) in rat heart cytosol
Clicks: 215
ID: 227156
2016
Article Quality & Performance Metrics
Overall Quality
Not rated
Combines reader engagement with the AI quality analysis. This
article has not been analysed, so there is no overall score —
reader engagement is measured and shown alongside.
Reader Engagement
Steady Performance
30.0
/100
215 views
27 readers
AI Quality Assessment
Not analyzed
Readership in this journal
SteadyRanked #202 of 437 articles by views in renewable energy
Most read
Least read
Bar heights use a square-root scale. Only the 120 most-read articles are drawn; the journal has 437 in total.
Mint this article as an NFT
Not yet mintedCreate a permanent, verifiable on-chain record of this article on the Scimatic Network. The NFT is held in your Journament account, and you can withdraw it to your own wallet at any time.
5
SUSD
one-off · no wallet required
Abstract
Background: Semicarbazide-sensitive amine oxidase (SSAO; EC; 1.4.3.6.) has widespread tissue distribution, and the physiological role of SSAO is quite well known through its involvement in several pathological states.
Aims: The present study examined modulators of SSAO which might be present in the rat heart cytosol and looked for changes in SSAO modulatory activity.
Methods: An endogenous inhibitor of SSAO was separated by gel filtration from 105,000 g supernate of T4-treated rat heart cytosol. SSAO inhibition fraction was referred to as “endogenous SSAO inhibitor”.
Results: The inhibition by this inhibitor was concentration-dependent. Inhibition of SSAO was not enhanced by varying the time of preincubation of the enzyme, indicating reversible inhibition of SSAO. The molecular weight of this inhibitor was estimated to be 1000–1100 by gel filtration. The isoelectric point (pI) value was determined to be 4.8 isoelectric focusing. This inhibitor was found to be heat-stable and resistant to protease treatment. SSAO inhibition activity was much lower in the cytosol of thyroidectomized, non-T4-treated rats than T4-treated rats, suggesting that this inhibitor was induced by thyroid hormone T4. SSAO activity in rat heart might be regulated by the level of this inhibitor.
Conclusion: These results suggest the presence of SSAO inhibitor in T4-treated rat cytosol and that the level of this inhibitor is regulated by thyroid hormone.
| Reference Key |
obata2016indianevidence
Use this key to autocite in the manuscript while using
SciMatic Manuscript Manager or Thesis Manager
|
|---|---|
| Authors | ;Toshio Obata;Michiko Nakashima |
| Journal | renewable energy |
| Year | 2016 |
| DOI |
10.1016/j.ihj.2016.01.011
|
| URL | |
| Keywords |
Citations
No citations found. To add a citation, contact the admin at info@scimatic.org
Comments
No comments yet. Be the first to comment on this article.