morphological and quantitative analysis of the neurons of the myenteric plexus of the cecum of streptozotocin-induced diabetic rats análise morfológica e quatitativa dos neurônios do plexo mientérico do ceco de ratos diabéticos induzidos por estreptozootocina

Clicks: 219
ID: 227074
1997
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Abstract
The purpose of this work was to study the neurons of the myenteric plexus of the cecum of rats with chronic streptozotocin-induced diabetes. We used four experimental groups of animals. In groups D2 and D8 animals were killed two and eight months, respectively, after diabetes induction and groups C2 and C8 were used as controls. We carried out whole-mount preparations stanied with Giemsa and NADH-diaphorase. We verified that the diabetes did not alter the shape and disposition of the myenteric ganglia; it provoked decrease on the neuronal density and increase on the incidence of weakly basophilic neurons. The effects of streptozotocin caused dilatation of the cecum still evidenced two months after induction, but no more observed on the eight months after induction. The smaller incidence of neurons in group D8 relative to group C8 was due to the early loss related to the drug toxicity and later to the aging in diabetic condition.
O objetivo deste trabalho foi estudar os neurônios do plexo mientérico do ceco de ratos, com diabetes mellitus crônico, induzido por estreptozootocina. Utilizamos quatro grupos de animais. Nos grupos D2 e D8, os animais foram mortos, dois e oito meses, respectivamente, após à indução do diabetes e os grupos C2 e C8 foram controles dos grupos experimentais. Realizamos preparados de membrana corados pelo método de Giemsa e NADH-diaforase. Verificamos que o diabetes não alterava a forma e a disposição dos gânglios do plexo mientérico; provocou redução da densidade neuronal e aumento da freqüência de neurônios fracamente basofílicos. Os efeitos da estreptozootocina provocavam dilatação do ceco ainda evidenciada dois meses após a indução, porém não mais verificada no oitavo mês após indução. A menor freqüência de neurônios no grupo D8 em relação ao grupo C8 deve-se a perda inicial relacionada à toxicidade da droga e posteriormente ao envelhecimento em condição de diabetes.
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Authors ;Jacqueline Nelisis Zanoni;Marcilio Hubner de Miranda-Neto;Roberto Barbosa Bazotte;Romeu Rodrigues de Souza
Journal communications in computer and information science
Year 1997
DOI
10.1590/S0004-282X1997000500004
URL
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X1997000500004
Keywords
diabetes mellitus neuropsychiatry biological psychiatry

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