speech sound discrimination training improves auditory cortex responses in a rat model of autism

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ID: 226851
2014
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Abstract
Children with autism often have language impairments and degraded cortical responses to speech. Extensive behavioral interventions can improve language outcomes and cortical responses. Prenatal exposure to the antiepileptic drug valproic acid (VPA) increases the risk for autism and language impairment. Prenatal exposure to VPA also causes weaker and delayed auditory cortex responses in rats. In this study, we document speech sound discrimination ability in VPA exposed rats and document the effect of extensive speech training on auditory cortex responses. VPA exposed rats were significantly impaired at consonant, but not vowel, discrimination. Extensive speech training resulted in both stronger and faster anterior auditory field responses compared to untrained VPA exposed rats, and restored responses to control levels. This neural response improvement generalized to non-trained sounds. The rodent VPA model of autism may be used to improve the understanding of speech processing in autism and contribute to improving language outcomes.
Reference Key
engineer2014frontiersspeech Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Crystal T Engineer;Tracy M Centanni;Kwok W Im;Michael P Kilgard
Journal Vacuum
Year 2014
DOI
10.3389/fnsys.2014.00137
URL
http://journal.frontiersin.org/Journal/10.3389/fnsys.2014.00137/full
Keywords
autism speech rehabilitation plasticity auditory cortex neuropsychiatry biological psychiatry

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