oxcarbazepine induced hyponatremia: a potential explanation of its physiopathology
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2009
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Abstract
Carbamazepine and oxcarbazepine are antiepileptic drugs which can induce hyponatremia, being this disorder more frequent with the latter.In this report we present a clinical case regarding an oxcarbazepine induced hyponatremia, and we hypothesized that oxcarbazepine could induce hyponatremia as a consequence of its influence on distal nephron where it could promote free water retention, urinary sodium loss, or both of them.Besides, we proposed that a greater tubular sesitivity to oxcarbazepine than to carbamazepine could explain the different hyponatremia inducing capability between these two drugs
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| Authors | ;Musso CG;Vilas M;Aparicio C;Bevione P;Reynaldi J;Rojas J;Jauregui R;Algranati L |
| Journal | animal models and experimental medicine |
| Year | 2009 |
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