synthesis and physical-chemical properties of 3-(alkylthio)-4-r-5-(thiophen-2-ylmethyl)-4h-1,2,4-triazoles
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ID: 226392
2015
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Abstract
Aim. Selection, synthesis and biological properties of new compound play major role in creating original medicines.
Methods and results. Therefore, to find new bioactive compounds 3-(alkylthio)-4-R-5-(thiophene-2-ylmethyl)-4H-1,2,4-triazoles, where R - methyl, ethyl, phenyl, have been synthesized, by alkylation reaction of 4-R-5-(thiophene-2-ylmethyl)-4H-1,2,4-triazole-3-thiols with 1-bromobutane, or 1-bromopentane, or 1-bromohexane, 1-bromoheptane, 1-bromooctane, 1-bromononane, 1-bromodekane in the n-butanol medium and their physical-chemical properties have been studied using modern physical-chemical methods of analysis, elemental analysis, IR spectroscopy, and their individuality using HPLC-MS.
Conclusion. This suggests the possibility of further studying the biological effect of the synthesized compounds.
| Reference Key |
suhak2015aktualnsynthesis
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|---|---|
| Authors | ;O. A. Suhak;O. I. Panasenko;Ye. G. Knysh |
| Journal | current opinion in structural biology |
| Year | 2015 |
| DOI |
10.14739/2409-2932.2015.2.45130
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| URL | |
| Keywords | Keywords not found |
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