artemisinin prevents glutamate-induced neuronal cell death via akt pathway activation
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2018
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Abstract
Artemisinin is an anti-malarial drug that has been in use for almost half century. Recently, novel biological effects of artemisinin on cancer, inflammation-related disorders and cardiovascular disease were reported. However, neuroprotective actions of artemisinin against glutamate-induced oxidative stress have not been investigated. In the current study, we determined the effect of artemisinin against oxidative insult in HT-22 mouse hippocampal cell line. We found that pretreatment of artemisinin declined reactive oxygen species (ROS) production, attenuated the collapse of mitochondrial membrane potential induced by glutamate and rescued HT-22 cells from glutamate-induced cell death. Furthermore, our study demonstrated that artemisinin activated Akt/Bcl-2 signaling and that neuroprotective effect of artemisinin was blocked by Akt-specific inhibitor, MK2206. Taken together, our study indicated that artemisinin prevented neuronal HT-22 cell from glutamate-induced oxidative injury by activation of Akt signaling pathway.
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lin2018frontiersartemisinin
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| Authors | ;Shao-Peng Lin;Shao-Peng Lin;Wenjun Li;Ali Winters;Ran Liu;Shao-Hua Yang |
| Journal | macromolecular bioscience |
| Year | 2018 |
| DOI |
10.3389/fncel.2018.00108
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