severe anemia due to parvovirus b19 in a silver haired boy

فقر دم شديد ناجم عن فيروس بارفو B19 لدى صبي ذي شعر فضي

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ID: 225714
2016
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Abstract
Griscelli syndrome (GS) is a rare autosomal recessive immunodeficiency disorder in which the affected children present with characteristic silvery-white hairs. The hair microscopy of these children is characteristic and is helpful in differentiating GS from Chediak-Higashi syndrome which also presents with immunodeficiency and silver hairs. We report a 17-month-old boy with GS type 2 who presented with severe anemia. Bone marrow examination of the child suggested parvovirus B19 as the cause of severe anemia, which was later confirmed by DNA polymerase chain reaction.
تُعد متلازمة غريسيلي (GS) اضطراب عوز مناعي نادر ينتقل بالوراثة الجسدية المتنحية، ويتظاهر فيه الأطفال المصابون بشعر مميز بلون أبيض فضي. ويُعد الفحص المجهري للشعر لدى هؤلاء الأطفال نوعياً ومفيداً في التمييز بين متلازمة غريسيلي ومتلازمة تشيدياق-هيغاشي، التي تتظاهر هي الأخرى بنقص مناعة وشعر فضي. نُورد هنا تقريراً عن طفل يبلغ من العمر 17 شهراً مصاب بالنوع الثاني من متلازمة غريسيلي راجع بفقر دم وخيم. وقد رجّح فحص نخاع العظم للطفل أن يكون فيروس البارفو ب19 (Parvovirus B19) هو المسبب لفقر الدم الشديد، وهو ما جرى تأكيده لاحقاً بواسطة تفاعل البوليميراز المتسلسل للحمض النووي (DNA PCR).
Reference Key
verma2016indiansevere Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Nishant Verma;Archana Kumar;Rashmi Kushwaha
Journal journal of materials processing technology
Year 2016
DOI
10.4103/0377-4929.178228
URL
http://www.ijpmonline.org/article.asp?issn=0377-4929;year=2016;volume=59;issue=1;spage=110;epage=112;aulast=Verma
Keywords
anemia parvovirus immunodeficiency silver hairspathologymicrobiology

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