Sialyl Lewis-P-selectin cascade mediates tumor-mesothelial adhesion in ascitic fluid shear flow.

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ID: 22554
2019
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Abstract
Organ-specific colonization suggests that specific cell-cell recognition is essential. Yet, very little is known about this particular interaction. Moreover, tumor cell lodgement requires binding under shear stress, but not static, conditions. Here, we successfully isolate the metastatic populations of cancer stem/tumor-initiating cells (M-CSCs). We show that the M-CSCs tether more and roll slower than the non-metastatic (NM)-CSCs, thus resulting in the preferential binding to the peritoneal mesothelium under ascitic fluid shear stress. Mechanistically, this interaction is mediated by P-selectin expressed by the peritoneal mesothelium. Insulin-like growth factor receptor-1 carrying an uncommon non-sulfated sialyl-Lewis (sLe) epitope serves as a distinct P-selectin binding determinant. Several glycosyltransferases, particularly α1,3-fucosyltransferase with rate-limiting activity for sLe synthesis, are highly expressed in M-CSCs. Tumor xenografts and clinical samples corroborate the relevance of these findings. These data advance our understanding on the molecular regulation of peritoneal metastasis and support the therapeutic potential of targeting the sLe-P-selectin cascade.
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li2019sialylnature Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Li, Shan-Shan;Ip, Carman K M;Tang, Matthew Y H;Tang, Maggie K S;Tong, Yin;Zhang, Jiangwen;Hassan, Ayon Ahmed;Mak, Abby S C;Yung, Susan;Chan, Tak-Mao;Ip, Philip P;Lee, Cheuk Lun;Chiu, Philip C N;Lee, Leo Tsz On;Lai, Hung-Cheng;Zeng, Jin-Zhang;Shum, Ho Cheung;Wong, Alice S T;
Journal Nature communications
Year 2019
DOI
10.1038/s41467-019-10334-6
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