cell signaling underlying epileptic behavior

Clicks: 169
ID: 225525
2011
Free PDF
Article Quality & Performance Metrics
Overall Quality Improving Quality
0.0 /100
Combines engagement data with AI-assessed academic quality
AI Quality Assessment
Not analyzed
Abstract
Epilepsy is a complex disease, characterized by the repeated occurrence of bursts of electrical activity (seizures) in specific brain areas. The behavioral outcome of seizure events strongly depends on the brain regions that are affected by overactivity. Here we review the intracellular signaling pathways involved in the generation of seizures in epileptogenic areas. Pathways activated by modulatory neurotransmitters (dopamine, norepinephrine and serotonin), involving the activation of extracellular-regulated kinases (ERKs) and the induction of immediate early genes (IEGs) will be first discussed in relation to the occurrence of acute seizure events. Activation of immediate early genes has been proposed to lead to long-term molecular and behavioral responses induced by acute seizures. We also review deleterious consequences of seizure activity, focusing on the contribution of apoptosis-associated signaling pathways to the progression of the disease. A deep understanding of signaling pathways involved in both acute and long-term responses to seizures continues to be crucial to unravel the origins of epileptic behaviors and ultimately identify novel therapeutic targets for the cure of epilepsy.
Reference Key
ebozzi2011frontierscell Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Yuri eBozzi;Yuri eBozzi;Mark eDunleavy;Mark eDunleavy;David eHenshall
Journal lasers in manufacturing and materials processing
Year 2011
DOI
10.3389/fnbeh.2011.00045
URL
http://journal.frontiersin.org/Journal/10.3389/fnbeh.2011.00045/full
Keywords
dopamine apoptosis hippocampus serotonin c-fos neuropsychiatry biological psychiatry

Citations

No citations found. To add a citation, contact the admin at info@scimatic.org

Comments

No comments yet. Be the first to comment on this article.