high levels of cxcl8 and low levels of cxcl9 and cxcl10 in women with maternal rhd alloimmunization
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ID: 225100
2017
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Abstract
Maternal RhD alloimmunization is an inflammatory response against protein antigens in fetal red blood cells (RBC). However, not all women become alloimmunized when exposed to RhD+ fetal RBC. Thus, this study aimed to evaluate levels of inflammatory chemokines in RhD− pregnant women with erythrocyte alloimmunization. CXCL8, CXCL9, CCL5, and CXCL10 levels were determined from cell culture supernatants by flow cytometry in 46 (30 non-alloimmunized RhD− and 16 previously alloimmunized RhD−) pregnant women. CXCL8 levels were significantly higher (P < 0.004), and CXCL9 (P < 0.008) and CXCL10 (P < 0.003) levels were significantly lower in alloimmunized pregnant women. No significant difference in CCL5 levels was detected between the groups. Fetal RHD genotyping was performed in the alloimmunized RhD− group by real-time PCR. Anti-D alloantibody was detected in 10 mothers and anti-D and -C in six mothers. Twelve fetuses were RHD positive and four were RHD negative. Further studies of serum chemokines and placenta tissue could provide a better understanding of the cells involved in the pathogenesis of maternal erythrocyte alloimmunization.
| Reference Key |
schettini2017frontiershigh
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| Authors | ;Juliana Araújo de Carvalho Schettini;Juliana Araújo de Carvalho Schettini;Thomás Virgílio Gomes;Alexandra Karla Santos Barreto;Claudeir Dias da Silva Júnior;Marina da Matta;Isabela Cristina Neiva Coutinho;Maria do Carmo Valgueiro Costa de Oliveira;Leuridan Cavalcante Torres |
| Journal | sudebno-meditsinskaia ekspertiza |
| Year | 2017 |
| DOI |
10.3389/fimmu.2017.00700
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| URL | |
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