biophysical insights into the inhibitory mechanism of non-nucleoside hiv-1 reverse transcriptase inhibitors

Clicks: 215
ID: 224973
2013
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Abstract
HIV-1 reverse transcriptase (RT) plays a central role in HIV infection. Current United States Federal Drug Administration (USFDA)-approved antiretroviral therapies can include one of five approved non-nucleoside RT inhibitors (NNRTIs), which are potent inhibitors of RT activity. Despite their crucial clinical role in treating and preventing HIV-1 infection, their mechanism of action remains elusive. In this review, we introduce RT and highlight major advances from experimental and computational biophysical experiments toward an understanding of RT function and the inhibitory mechanism(s) of NNRTIs.
Reference Key
sluis-cremer2013biomoleculesbiophysical Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Nicolas Sluis-Cremer;Grant Schauer;Sanford Leuba
Journal international journal of middle east studies
Year 2013
DOI
10.3390/biom3040889
URL
http://www.mdpi.com/2218-273X/3/4/889
Keywords
mechanism biophysics

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