translating tolerogenic therapies to the clinic – where do we stand?

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ID: 224834
2012
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Abstract
Manipulation of the immune system to prevent the development of a specific immune response is an ideal strategy to improve outcomes after transplantation. A number of experimental techniques exploiting central and peripheral tolerance mechanisms have demonstrated success, leading to the first early phase clinical trials for tolerance induction. The first major strategy centres on the facilitation of donor-cell mixed chimerism in the transplant recipient with the use of bone marrow or haematopoietic stem cell transplantation. The second strategy, utilising peripheral regulatory mechanisms, focuses on cellular therapy with regulatory T cells. This review examines the key studies and novel research directions in the field of immunological tolerance.
Reference Key
eissa2012frontierstranslating Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Fadi eIssa;Kathryn J. Wood
Journal sudebno-meditsinskaia ekspertiza
Year 2012
DOI
10.3389/fimmu.2012.00254
URL
http://journal.frontiersin.org/Journal/10.3389/fimmu.2012.00254/full
Keywords
clinical trials transplantation tolerance regulatory t cell chimerism allergy

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