hplc–ms and hplc–ms/ms analysis of seven active constituents of xiao-xu-ming decoction and application to a pharmacokinetic study after oral administration to rat
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2012
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Abstract
Xiao-xu-ming decoction (XXMD) is a traditional Chinese medicine that has been widely used to treat theoplegia and its sequelae. This paper reports the development of three separate assays based on reversed phase high-performance liquid chromatography–mass spectrometry (HPLC–MS) and HPLC–MS/MS for the determination of seven active constituents of XXMD viz oroxylin A-7-O-glucuronide, wogonoside, liquiritigenin, cimifugin, 5-O-methylvisammiol, glycyrrhizic acid and glycyrrhetinic acid in rat plasma. All calibration curves were linear (r >0.99) with lower limits of quantitation (LLOQs)<12.4 ng/mL. Intra- and inter-day precisions (as relative standard deviation) were all <10.7% with recoveries in the range of 88.7–113%. In addition, the seven analytes were shown to be stable in rat plasma samples under relevant storage conditions. The validated methods were successfully applied to a pharmacokinetic study in rat after oral administration of XXMD.
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| Reference Key |
wang2012actahplcms
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|---|---|
| Authors | ;Yilin Wang;Chunguang Ding;Caisheng Wu;Kehe Du;Jinlan Zhang;Hailin Qin;Jinfeng Hou;Guanhua Du |
| Journal | energy policy |
| Year | 2012 |
| DOI |
10.1016/j.apsb.2012.01.003
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| URL | |
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