effect of non-surgical periodontal therapy on interleukin-29 levels in gingival crevicular fluid of chronic periodontitis and aggressive periodontitis patients

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ID: 223289
2013
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Abstract
Recently discovered interleukin 29 (IL-29) has antiviral properties and its production is induced by herpes viruses. This study was aimed at analyzing the effect of non-surgical periodontal treatment on IL-29 levels in gingival crevicular fluid (GCF) of chronic and aggressive periodontitis patients. A total of 60 participants were divided into healthy group (group 1; n = 20), chronic periodontitis group (group 2; n = 20), and aggressive periodontitis group (group 3; n = 20). GCF samples collected from each subject at baseline and 6–8 weeks after scaling and root planing were quantified for IL-29 levels using ELISA. The mean IL-29 concentration in GCF was found to be highest in group 3 (92.37 pg/μl). The mean IL-29 level in group 1 and group 2 was 36.88 pg/μl and 69.35 pg/μl respectively. After scaling and root planing, the mean concentration of IL-29 in GCF was increased to 85.99 pg/μl in group 2 and to 114.64 pg/μl in group 3. Results of the present study indicate that antiviral IL-29 level was highest in GCF of aggressive periodontitis patients and least in subjects with healthy periodontium, while that of chronic periodontitis lying in between. After non-surgical periodontal therapy, IL-29 levels increased both in chronic and aggressive periodontitis patients and deserve further investigation as a potential therapeutic agent in treating periodontitis.
Reference Key
shivaprasad2013diseaseeffect Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors B. M. Shivaprasad, A. R. Pradeep
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Journal international journal of psychology : journal international de psychologie
Year 2013
DOI
10.3233/DMA-2012-120944
URL
http://dx.doi.org/10.3233/DMA-2012-120944
Keywords
Medicine (General)

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