immune history and influenza vaccine effectiveness

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ID: 223086
2018
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Abstract
The imperfect effectiveness of seasonal influenza vaccines is often blamed on antigenic mismatch, but even when the match appears good, effectiveness can be surprisingly low. Seasonal influenza vaccines also stand out for their variable effectiveness by age group from year to year and by recent vaccination status. These patterns suggest a role for immune history in influenza vaccine effectiveness, but inference is complicated by uncertainty about the contributions of bias to the estimates themselves. In this review, we describe unexpected patterns in the effectiveness of seasonal influenza vaccination and explain how these patterns might arise as consequences of study design, the dynamics of immune memory, or both. Resolving this uncertainty could lead to improvements in vaccination strategy, including the use of universal vaccines in experienced populations, and the evaluation of vaccine efficacy against influenza and other antigenically variable pathogens.
Reference Key
lewnard2018vaccinesimmune Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Joseph A. Lewnard;Sarah Cobey
Journal Tuberkuloz ve toraks
Year 2018
DOI
10.3390/vaccines6020028
URL
http://www.mdpi.com/2076-393X/6/2/28
Keywords
vaccine effectiveness universal influenza vaccine imprintingmedicine

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