multiple sclerosis: a disorder of altered t-cell homeostasis

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ID: 223020
2011
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Abstract
Uncertainty exists as to whether similar or different mechanisms contribute to the pathogenesis of different subtypes of multiple sclerosis (MS). Detailed analysis of naive T cell homeostasis shows that patients with relapsing-remitting MS (RRMS) and with primary progressive MS (PPMS) have early-onset thymic involution that causes reduced thymic output. The reduced thymic output leads to secondary peripheral homeostatic alterations in naïve CD4 T-cells, which closely mimic T-cell alterations observed in an experimental animal model of diabetes mellitus. Homeostatic T-cell receptor (TCR) signalling and proliferation of naïve T cells are induced by self-peptides. Consequently, the findings of increased TCR signalling of naïve CD4 T-cells, without increased proliferation, in PPMS, and the increased homeostatic proliferation of naïve CD4 T-cells in RRMS favour the development of autoimmunity. Thus, it seems highly likely that peripheral T-cell alterations secondary to a thymic abnormality contribute to the pathogenesis of both MS subtypes.
Reference Key
haegert2011multiplemultiple Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;David G. Haegert
Journal acta cardiologica
Year 2011
DOI
10.1155/2011/461304
URL
http://dx.doi.org/10.1155/2011/461304
Keywords
neurology diseases of the nervous system

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